This includes several examples of the application of computer science in support of research activity in other disciplines. Achievements include the data management, security, and metadata work on the e-DiaMoND breast cancer imaging project, the design of a distributed computing architecture for climatePrediction.net, a world-wide experiment on climate, and the automatic generation of semantically-aware information systems for clinical research, used in five cancer centres in the UK and being evaluated for use in clinical trials run by the US Department for Veterans' Affairs.