Computational prediction of drug cardiotoxicity
Research Assistant (Four posts)
Grade 7: Salary £26,666 - £32,796 p.a.
PreDiCT 'Computational prediction of drug cardiotoxicity' is a recently-announced European Union project funded within the Virtual Physiological Human call. It aims to develop the computational tools and models, algorithms and methodologies required for the assessment of drug action in cardiac electromechanical behaviour. It is an international, multi-institutional and cross-disciplinary project team involving world experts on the theoretical and experimental techniques to study cardiac behaviour, and also major pharmaceutical companies.
Four research positions are available to work in a research team involving the Computational Biology Group at the Computing Laboratory and the Computational Physiology Research Group in the Department of Physiology, Anatomy and Genetics in the University of Oxford. The earliest starting date of the posts will be June 2nd, 2008, and the project will run until the end of May 2011.
The main aim is to model and simulate drug action on the heart from the ionic to the whole organ level to investigate mechanisms of drug-induced cardiac arrhythmias and new biomarkers for drug cardiotoxicity. The appointees will be expected to contribute to at least two of the following areas:
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Mathematical modelling of drug-induced effects on cardiac electrophysiological behaviour (from ionic to ventricular level);
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Development of mathematical models and computational algorithms required to simulate whole ventricular electromechanical behaviour (including drug action);
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Development of algorithms for model validation, analysis and comparison.
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Development of ECG signal processing algorithms to identify potential biomarkers for drug-induced pro-arrhythmic risk;
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Investigation of mechanisms of drug-induced cardiac arrhythmias using computational modelling in combination with clinical and experimental data.
Further particulars, including details on how to apply, for each of the posts can be obtained from the following links:
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Research Assistant Post (Grade 7)- Modelling drug action on cardiac cell electrophysiology. Cardiac Electrophysiology Group, Department of Physiology, Anatomy and Genetics. Reference AV08016, see www.dpag.ox.ac.uk/job_opportunities for further details.
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Two Research Assistant Posts (Grade 7)- Investigating mechanisms of drug-induced arrhythmias using computational modelling. Computational Biology Group, Oxford University Computing Laboratory, see for further details.
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Research Assistant Post (Grade 7)-Identification of new biomarkers of drug cardiotoxicity using signal processing and computational modelling techniques. Computational Biology Group, Oxford University Computing Laboratory see for further details.
The closing date for applications is 1 May.Interviews will be held in late May.
The policy and practice of the University of Oxford require that all staff are offered equal opportunities within employment. Entry into employment with the University and progression within employment will be determined only by personal merit and the application of criteria which are related to the duties of each particular post and the relevant salary structure. In all cases, ability to perform the job will be the primary consideration. Subject to statutory provisions, no applicant or member of staff will be treated less favourably than another because of his or her age, sex, marital or civil partnership status, sexual orientation, religion or belief, racial group or disability.
